Granulin exacerbates lupus nephritis via enhancing macrophage M2b polarization.
BACKGROUND Saute Pans AND AIMS: Lupus nephritis (LN), with considerable morbidity and mortality, is one of the most severe manifestations of systemic lupus erythematosus (SLE).Yet, the pathogenic mechanisms of LN have not been clearly elucidated, and efficient therapies are still in great need.Granulin (GRN), a multifunctional protein linked to inf